Entity Address, City or Town Entity Address, City or Town Entity Ex Transition Period Entity Ex Transition Period Fair Value Disclosures [Abstract] Earnings Per Share [Abstract] Level 1 [Member] Fair Value, Inputs, Level 1 [Member] Summary of Accrued Liabilities Schedule of Accrued Liabilities [Table Text Block] Issuance of common stock in connection with Follow-on Offering, net of offering costs Stock Issued During Period, Value, New Issues Research and development expenses Research and Development Expense, Policy [Policy Text Block] Cash flows from financing activities: Net Cash Provided by (Used in) Financing Activities [Abstract] Net decrease in cash, cash equivalents, and restricted cash Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Excluding Exchange Rate Effect Revenue from collaborations recognized in the period Revenue recognized from collaborative arrangements on upfront payment Revenue from customers recognized in the period Contract with customer liability revenue recognized on upfront payment. Amendment Flag Amendment Flag Subsequent Event Type [Domain] Operating lease right-of-use assets Operating Lease, Right-of-Use Asset Derivative Liabilities And Redeemable Convertible Preferred Stock Liability [Table] Derivative Liabilities And Redeemable Convertible Preferred Stock Liability [Table] Document Quarterly Report Document Quarterly Report S-antigen transport-inhibiting oligonucleotide polymers. S-antigen Transport-inhibiting Oligonucleotide Polymers [Member] STOPS Maturities of investments Proceeds from Sale of Debt Securities, Available-for-Sale Operating lease liabilities Increase Decrease In Operating Lease Liabilities Increase decrease in operating lease liabilities. Net loss per share Earnings Per Share, Policy [Policy Text Block] Derivative Liabilities And Convertible Preferred Stock Liability [Line Items] Derivative Liabilities And Convertible Preferred Stock Liability [Line Items] Derivative liabilities and convertible preferred stock liability [line items]. Statement [Table] Statement [Table] Lease liabilities net of current portion Operating lease liabilities, net of current portion Operating Lease, Liability, Noncurrent Interest on lease liabilities Finance Lease, Interest Expense Operating lease, payments Operating Lease, Payments Issuance of common stock related to ESPP purchase, shares Purchase of common stock Stock Issued During Period, Shares, Employee Stock Purchase Plans Preferred Stock, Shares Outstanding, Ending Balance Preferred Stock, Shares Outstanding, Beginning Balance Preferred Stock, Shares Outstanding Preferred Stock, Shares Outstanding Common stock available for future grant Common Stock, Capital Shares Reserved for Future Issuance Series B Preferred Stock [Member] Series B-1 Series B Preferred Stock [Member] Available-for-Sale, Amortized Cost, One year or less Debt Securities, Available-for-Sale, Amortized Cost, Maturity, Allocated and Single Maturity Date, Year One Weighted average granted fair date value - Beginning balance Weighted average granted fair date value - Ending balance Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Weighted average granted fair date value, vested Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Discontinued development of drug candidates. Discontinued Development of Drug Candidates [Abstract] Deferred revenue from collaborations Increase (Decrease) in Deferred Revenue Organization Nature of Operations [Text Block] Share based compensation expense recognized tax benefit Share-Based Payment Arrangement, Expense, Tax Benefit KU Leuven [Member] K U Leuven [Member] KU Leuven. Finance lease right of use assets accumulated amortization Finance Lease, Right-of-Use Asset, Accumulated Amortization Lab Equipment [Member] Lab Equipment [Member] Lab equipment. Katholieke Universiteit Leuven License Agreement [Member] Katholieke Universiteit Leuven License Agreement [Member] Katholieke Universiteit Leuven License Agreement. Employee-related Liabilities, Current, Total Accrued compensation Employee-related Liabilities, Current Disposal Group Classification [Domain] Options to purchase common stock [Member] Stock Option [Member] Share-Based Payment Arrangement, Option [Member] Weighted-average remaining lease term (years) Operating Lease, Weighted Average Remaining Lease Term Aggregate intrinsic value, Granted Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Aggregate Intrinsic Value Granted Share based compensation arrangement by share based payment award equity instruments other than options aggregate intrinsic value granted. Total liabilities and stockholders’ equity Liabilities and Equity Available-for-Sale, Estimated Fair Value, More than one year Available For Sale Securities Debt Maturities More Than One Year Fair Value Available for sale securities debt maturities more than one year fair value. Aggregate intrinsic value, Vested Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Vested Changes in fair value of the warrants Change in fair value of derivative liability upon exercise of warrants Fair Value Adjustment of Warrants Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Income Statement [Abstract] Reverse stock split Stockholders' Equity, Reverse Stock Split Activities in available-for-sale investments: Debt Securities, Available-for-Sale [Abstract] Weighted-average remaining lease term (years) Finance Lease, Weighted Average Remaining Lease Term Derivative Liabilities And Redeemable Convertible Preferred Stock Liability [Abstract] Derivative Liabilities And Redeemable Convertible Preferred Stock Liability [Abstract] Derivative Liability, Total Fair value of the warrants Derivative Liability Less: current portion Finance lease liabilities, current Finance Lease, Liability, Current Sale of Stock Sale of Stock [Domain] Total current liabilities Liabilities, Current Disclosure - Fair value - Summary of Fair Value of the Financial Instruments that are Measured at Fair Value on a Recurring Basis (Detail) [Abstract] Disclosure Fair Value Summary Of Fair Value Of Financial Instruments That Are Measured At Fair Value On Recurring Basis Detail [Abstract] Issuance of common stock related to ESPP purchase Stock Issued During Period, Value, Employee Stock Purchase Plan Offer expenses Offer Expenses Offer expenses. Accrued liabilities Accounts Payable and Accrued Liabilities Disclosure [Text Block] Fair value of warrants upon issuance Fair Value Of Warrants Upon Issuance Fair value of warrants upon issuance. Available-for-Sale, Amortized Cost, More than one year Available For Sale Securities Debt Maturities More Than One Year Amortized Cost Available for sale securities debt maturities more than one year amortized cost. Preferred Stock, Shares Authorized Preferred Stock, Shares Authorized Costs related to the Follow-on Offering Adjustments to Additional Paid in Capital, Stock Issued, Own-share Lending Arrangement, Issuance Costs Vesting of early exercised options Vesting Of Early Exercised Options Value Vesting of early exercised options value. Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table] Weighted-average discount rate Operating Lease, Weighted Average Discount Rate, Percent Entity Small Business Entity Small Business Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Total Cash, cash equivalents, and restricted cash, beginning of period Cash, cash equivalents, and restricted cash, end of period Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents Amoytop Amoytop [Member] Amoytop. Investments [Domain] Total current assets Assets, Current Property Plant And Equipment [Line Items] Property, Plant and Equipment [Line Items] Increase (Decrease) in Other Operating Liabilities, Total Other liabilities Increase (Decrease) in Other Operating Liabilities Weighted Average Number of Shares Outstanding, Basic, Total Weighted Average Number of Shares Outstanding, Basic Weighted average shares of common stock, basic Series B Two Preferred Stock [Member] Series B Two Preferred Stock [Member] Series B Two Preferred Stock [Member] City Area Code City Area Code Aggregate Intrinsic Value - Options outstanding Aggregate Intrinsic Value - Options outstanding Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value Number of options, Cancelled Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period Share-Based Payment Arrangement [Abstract] Merck license and research collaboration first amendment. Merck License and Research Collaboration First Amendment [Member] Merck License and Research Collaboration First Amendment [Member] Reconciliation to amounts on the consolidated balance sheet: Reconciliation To The Amounts On The Condensed Consolidated Balance Sheet [Abstract] Reconciliation to the amounts on the condensed consolidated balance sheet [Abstract]. Total liabilities Liabilities Document Period End Date Document Period End Date Unvested restricted stock [Member] Restricted Stock [Member] Restricted Stock [Member] Available-for-sale securities, Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost Statistical Measurement Statistical Measurement [Axis] Other current assets Other Assets, Current Subsequent Event [Line Items] Upfront license fees paid Upfront License Fees Paid Upfront license fees paid Vehicles [Member] Vehicles [Member] Related Party Related Party [Axis] Total assets Assets Elected extension term of collaboration agreement. Elected Extension Term of Collaboration Agreement Elected extension term of collaboration agreement Schedule of Deferred Revenue from Customers Disclosure Of Deferred Revenue From Customers [Table Text Block] Disclosure of deferred revenue from customers. Earnings Per Share, Diluted, Total Earnings Per Share, Diluted Net loss per share, diluted Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Revenue from customers related to upfront payments Revenue from customers recognized in the period Contract With Customer Liability Deferred Revenue Recognized on Upfront Payment Contract with customer liability deferred revenue recognized on upfront payment. Entity Address, Postal Zip Code Entity Address, Postal Zip Code Document Fiscal Period Focus Document Fiscal Period Focus Restricted Cash, Total Restricted cash Restricted Cash Schedule Of Available For Sale And Held To Maturity Securities Amortised Cost Gross Unrealised Gains Losses And Fair Value [Table] Schedule Of Available For Sale And Held To Maturity Securities Amortised Cost Gross Unrealised Gains Losses And Fair Value [Table] Schedule of available for sale and held to maturity securities amortised cost gross unrealised gains losses and fair value [Table]. Temporary equity shares converted into permanent equity Conversion of Stock, Shares Converted Preferred Stock, $0.0001 par value; 10,000,000 shares authorized as of March 31, 2023 (unaudited) and December 31, 2022, respectively; no shares issued and outstanding as of March 31, 2023 (unaudited) and December 31, 2022, respectively. 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Class of warrant or right, number of securities called by warrants or rights Class of Warrant or Right, Number of Securities Called by Warrants or Rights Warrants issued closing date Warrants Issued Closing Date Warrants issued closing date. Interest and other income (expense), net Other Operating Income (Expense), Net Statistical Measurement Statistical Measurement [Domain] Statement of Stockholders' Equity [Abstract] Sale of Stock Sale of Stock [Axis] Class of Stock Class of Stock [Domain] Loss Contingency Accrual, Ending Balance Loss Contingency Accrual, Beginning Balance Contingent liabilities Loss Contingency Accrual Deferred revenue from customers as of March 31 Deferred revenue from customers as of January 1 Deferred Revenue From Customers Deferred revenue from customers. Summary of Components of lease Expense Lease, Cost [Table Text Block] Subsequent Events [Abstract] Fair value Fair Value Disclosures [Text Block] Luxna license agreement [Member] Luxna License Agreement [Member] Luxna license agreement [Member] Other comprehensive income (loss): Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Weighted- Average Remaining Contractual Term, Options vested and exercisable Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Proceeds from the exercise of common stock option Proceeds from Stock Options Exercised Nature Of Operations [Table] Nature Of Operations [Table] Nature of operations [Table]. Summary of Property and Equipment Property, Plant and Equipment [Table Text Block] Revenue from customers recognized in the period Revenue from customers recognized in the period Contract With Customer Liability Deferred Revenue Recognized Contract with customer liability deferred revenue recognized. Summary of Stock Options Disclosure of Share-Based Compensation Arrangements by Share-Based Payment Award [Table Text Block] Revenue from contracts with customers Revenue from Contract with Customer [Text Block] Antidilutive Securities Antidilutive Securities [Axis] Merck License and Research Collaboration [Member] Merck License And Research Collaboration [Member] Merck license and research collaboration. Merck License and Research Collaboration Preferred stock authorized par value Preferred Stock, Par Value Preferred Stock, Par or Stated Value Per Share Available-for-sale securities, Gross Unrealized Gain Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax Lessee Lease Description [Line Items] Lessee, Lease, Description [Line Items] Cash, Cash Equivalents, and Short-term Investments, Total Unrestricted cash, Cash equivalent and investment Cash, Cash Equivalents, and Short-Term Investments First commercial sale of a licensed product period First Commercial Sale Of A Licensed Product Period First commercial sale of a licensed product period. Subsequent events Subsequent Events [Text Block] Weighted Average Number of Shares Outstanding, Diluted, Total Weighted Average Number of Shares Outstanding, Diluted Weighted average shares of common stock, diluted Computer equipment [Member] Computer Equipment [Member] Computer Equipment [Member] General and Administrative [Member] General and Administrative Expense [Member] Research and Development Arrangement, Contract to Perform for Others, Type Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Current Fiscal Year End Date Current Fiscal Year End Date Investment Type [Axis] Liability Class Liability Class [Axis] Depreciation, Total Depreciation expense Depreciation Financial Instruments [Domain] The entire disclosure of discontinued development of drug candidates. 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Compensation Related Costs [Abstract] Income tax expense Income Tax Expense (Benefit), Total Income Tax Expense (Benefit) Milestone payments and royalties receivable Milestone Payments And Royalties Receivable Milestone payments and royalties receivable. Shares of common stock held by employees subject to repurchase Weighted Average Number of Shares, Common Stock Subject to Repurchase or Cancellation Income taxes Income Tax Disclosure [Text Block] Preferred Stock, Shares Issued, Total Preferred Stock, Shares Issued Preferred Stock, Shares Issued Other Other Accrued Liabilities, Current Payments to Acquire Property, Plant, and Equipment, Total Payments to Acquire Property, Plant, and Equipment Purchases of property and equipment Purchases of property and equipment Income Tax Disclosure [Abstract] Non-refundable payment Long-Term Purchase Commitment, Amount Stock issued during the period new issues shares Issuance of common stock in connection with Follow-on Offering, net of offering costs, shares Stock Issued During Period, Shares, New Issues Deferred offering costs Deferred Offering Costs Policy [Text Block] Deferred offering costs [Policy text block]. 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Entity Filer Category Entity Filer Category Forward contract to issue redeemable convertible preferred stock [Member] Forward Contracts [Member] Deferred Revenue from collaborations, current Deferred Revenue From Collaboration Current Deferred revenue from collaborations current. Deferred revenue from collaborations, current Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Other comprehensive loss Other comprehensive income (loss) Other comprehensive income (loss) Total operating expenses Operating Expenses Fair Value by Liability Class Fair Value by Liability Class [Domain] Entity Current Reporting Status Entity Current Reporting Status Asset Class Asset Class [Domain] Conversion of Stock, Name Conversion of Stock, Name [Domain] Percentage of principal amount of notes covered by warrants Percentage Of Principal Amount Of Notes Covered By Warrants Percentage of principal amount of notes covered by warrants. Capital stock Stockholders' Equity Note Disclosure [Text Block] License and collaboration agreements License And Collaboration Agreements [Text Block] License and collaboration agreements text block. Total stockholders’ equity Beginning balance Ending balance Stockholders' Equity Attributable to Parent Derivative liabilities and convertible preferred stock liability Derivative Liabilities And Redeemable Convertible Preferred Stock Liability [Text Block] Derivative liabilities and redeemable convertible preferred stock liability. 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Cash equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Payments for royalties Payments for Royalties Leases [Abstract] APIC, Share-Based Payment Arrangement, Other, Increase for Cost Recognition Stock-based compensation expense related to employee stock awards Purchase of short-term investments Payments to Acquire Short-Term Investments Entity Emerging Growth Company Entity Emerging Growth Company Operating expenses: Operating Expenses [Abstract] Investment In Available For Sale And Held To Maturity Securities [Table] Investment In Available For Sale And Held To Maturity Securities [Table] Investment in available for sale and held to maturity securities [Table]. Revenue from collaborations Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer Document Transition Report Document Transition Report Sale of Stock, Number of Shares Issued in Transaction Sale of Stock, Number of Shares Issued in Transaction Fair value, assets Assets, Fair Value Disclosure Weighted average granted fair date value, granted Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Voting Common Stock [Member] Voting Common Stocks [Member] Voting common stocks. Warrants issued expiry period Warrants And Rights Outstanding Maturity Period Warrants and rights outstanding maturity period. 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Disclosure - License and collaboration agreements - Additional Information (Detail) [Abstract] Disclosure License And Collaboration Agreements Additional Information Detail [Abstract] Document Type Document Type Entity Shell Company Entity Shell Company Conversion Of Stock Voting Shares [Member] Conversion Of Stock Voting Shares [Member] Conversion of stock voting shares. Allocated Share Based Compensation Expense Share based compensation expense Share-Based Payment Arrangement, Expense Warrants exercised Warrants Exercised Warrants exercised. Security Exchange Name Security Exchange Name Revenue from Contract with Customer [Abstract] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Lease liabilities net of current portion Finance lease liabilities, net of current portion Finance Lease, Liability, Noncurrent Liability for early exercised stock options Liability For Early Exercised Stocks Options Current Liability for early exercised stock options current. Liability for early exercised stock options Summary of significant accounting policies Significant Accounting Policies [Text Block] Net cash and cash equivalents used in operating activities Net Cash Provided by (Used in) Operating Activities Mark to market adjustment for available-for-sale investments Market To Market Adjustments For Available For Sale Investments Market to market adjustments for available for sale investments. Share based payment expenses amortized over a weighted average period Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Weighted- Average Remaining Contractual Term, Outstanding Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Commitments and Contingencies Disclosure [Abstract] Summary of Estimated Useful Life of Asset Schedule Of Estimated Useful Life Of Asset Table [Text Block] Schedule of estimated useful life of asset. Operating lease cost Operating Lease, Cost Summary of Maturities of Lease Liabilities Lessee, Operating Lease, Liability, Maturity [Table Text Block] Deferred revenue from collaborations Deferred Revenue From Collaboration Non Current Deferred revenue from collaborations noncurrent. 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Aggregate Intrinsic Value - Exercised Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value Discontinued Operations and Disposal Groups [Abstract] Research and Development Expense, Total Research and development Research and Development Expense Entity Central Index Key Entity Central Index Key Short-term Investments, Total Short-term investments Short-Term Investments Unaudited interim financial information Unaudited Interim Financial Information Policy [Text Block] Unaudited interim financial information. 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Research plan expiry period Research And Development Arrangement Contract To Perform For Others Expiry Period Research and development arrangement contract to perform for others expiry period. Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Accumulated Deficit Retained Earnings [Member] Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Right of use assets Increase Decrease In Right Of Use Assets Increase decrease in right of use assets. Right of use assets Deferred revenue from customers, current Deferred Revenue from Customers Current Deferred revenue from customers current. Schedule Of Additional Information Related To The Leases [Abstract] Schedule of additional information related to the leases Research and Development Arrangement, Contract to Perform for Others, Type Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Property, Plant and Equipment, Gross, Ending Balance Property, Plant and Equipment, Gross, Beginning Balance Property, Plant and Equipment, Gross, Total Total, at cost Property, Plant and Equipment, Gross Expense or accruals recognized related to royalties Expense Or Accruals Recognized Related To Royalties Expense or accruals recognized related to royalties. Amortization of right-of-use assets Finance Lease Amortization Of Right Of Use Assets Finance lease amortization of right of use assets. Significant accounting policies and estimates Policy text block Significant accounting policies and estimates Policy text block Significant accounting policies and estimates Entity Interactive Data Current Entity Interactive Data Current Assets: Financial Instruments, Financial Assets, Balance Sheet Groupings [Abstract] Number of options vested and expected to vest Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Supplemental disclosures of noncash financing and investing activities: Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Schedule of Deferred Revenue from Collaborative Arrangements Disclosure of Deferred Revenue from Collaborations [Table Text Block] Disclosure of deferred revenue from collaborations. Research and Development Arrangement, Contract to Perform for Others, Costs Incurred, Gross Funding related to collaboration agreement extension Leasehold improvements [Member] Leasehold Improvements [Member] Leasehold Improvements [Member] Asset under construction [Member] Asset under Construction [Member] Finance lease cost: Finance Lease Costs [Abstract] Finance lease costs. Beginning balance, Shares Ending balance, Shares Temporary Equity, Shares Outstanding Local Phone Number Local Phone Number Expense related to milestone payments Expense Related To Milestone Payments Expense related to milestone payments. Summary of fair value of the financial instruments that are measured at fair value on a recurring basis Fair Value, Assets Measured on Recurring Basis [Table Text Block] Deferred revenue from customers, net of current portion Deferred Revenue from Customers, Non Current Deferred revenue from customers non current. Common stock issued upon exercise of stock options Stock Issues Early Period Share Stock Options Exercised Stock issues early period share stock options exercised. Schedule of Earnings Per Share, Basic and Diluted Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Basis of presentation Basis of Accounting, Policy [Policy Text Block] Number of options vested and exercisable Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number IPO IPO [Member] Number of options, Granted Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Other Liabilities, Noncurrent, Total Other liabilities Other Liabilities, Noncurrent Income Statement Location Income Statement Location [Domain] Property, Plant and Equipment [Abstract] Number of awards - Beginning balance Number of awards - Ending balance Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number Beginning balance, Shares Ending balance, Shares Shares, Outstanding Katholieke Universiteit Leuven [Member] Katholieke Universiteit Leuven [Member] Katholieke Universiteit Leuven. Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Number of options - Beginning balance Number of options - Ending balance Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number Luxna biotech Co Ltd [Member] Luxna Biotech Co Ltd [Member] Luxna biotech Co Ltd [Member] Document Fiscal Year Focus Document Fiscal Year Focus Purchase Obligation, Total Non-cancellable purchase commitments Purchase Obligation Debt Securities, Available-for-Sale and Held-to-Maturity, after Allowance for Credit Loss [Abstract] Earnings Per Share, Basic, Total Earnings Per Share, Basic Net loss per share, basic Antisense Oligonucleotide. Antisense Oligonucleotide [Member] Antisense Oligonucleotide Summary Of Available For Sale And Held To Maturity Securities Amortized Cost Gross Unrealized Gains Losses And Fair Value Table [Text Block] Summary of available for sale and held to maturity securities amortized cost gross unrealized gains losses and fair value. Summary of Available For Sale Securities Amortized Cost Gross Unrealized Gains Losses and Fair Value ASSETS Assets [Abstract] Increase (Decrease) in Accrued Liabilities, Total Accrued liabilities Increase (Decrease) in Accrued Liabilities Investments, Fair Value Disclosure, Total Fair value, assets Investments, Fair Value Disclosure Series A Preferred Stock [Member] Series A Series A Preferred Stock [Member] Financial Instrument [Axis] Long-Lived Tangible Asset Long-Lived Tangible Asset [Axis] Investment In Available For Sale And Held To Maturity Securities [Line Items] Investment In Available For Sale And Held To Maturity Securities [Line Items] Investment in available for sale and held to maturity securities. LIABILITIES, PREFERRED STOCK, AND STOCKHOLDERS EQUITY Liabilities and Equity [Abstract] APIC, Share-Based Payment Arrangement, ESPP, Increase for Cost Recognition Stock-based compensation expense related to employee stock purchases Property and equipment Property, Plant and Equipment, Policy [Policy Text Block] Antidilutive Securities, Name Antidilutive Securities, Name [Domain] Mandatorily Redeemable Preferred Stock [Member] Mandatorily Redeemable Preferred Stock [Member] Current assets: Assets, Current [Abstract] License And Collaboration Agreements [Abstract] License and collaboration agreements [Abstract] Warrants exercise price per share Class of Warrant or Right, Exercise Price of Warrants or Rights Fair Value Hierarchy and NAV Fair Value Hierarchy and NAV [Domain] Payables and Accruals [Abstract] Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan [Member] Employee stock purchase plan. Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Long term purchase commitment additional obligation to be paid Long Term Purchase Commitment Additional Obligation To Be Paid Long term purchase commitment additional obligation to be paid. Lease, Cost [Abstract] Cover [Abstract] Number of awards, vested Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Current liabilities: Liabilities, Current [Abstract] Maximum [Member] Maximum [Member] Aggregate price for share repurchase. Aggregate price for share repurchase Aggregate price for share repurchase Summary of Stock Based Compensation Expense Was Allocated Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Merck [Member] Merck [Member] Merck. Merck Net cash and cash equivalents provided by (used in) investing activities Net Cash Provided by (Used in) Investing Activities Furniture and office equipment [Member] Furniture and Office Equipment [Member] Furniture and Fixtures [Member] Servicing Liability at Fair Value, Period Increase (Decrease), Total Change in fair value of liability Servicing Liability at Fair Value, Period Increase (Decrease) Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Number of options, Exercised Issuance of common stock upon exercise of stock options, shares Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period Emory university [Member] Emory University [Member] Emory university [Member] Level 3 [Member] Fair Value, Inputs, Level 3 [Member] Long term purchase commitment period description Longterm Purchase Commitment Period Description Long term purchase commitment period description. Use of estimates Use of Estimates, Policy [Policy Text Block] Convertible notes issued for purchasing license Notes Issued Collaboration expire period Long-Term Purchase Commitment, Period Issuance of common stock upon exercise of stock options Stock Issued During Period, Value, Stock Options Exercised Segment information Segment Reporting, Policy [Policy Text Block] Long-term Investments, Total Long-term investments Long-Term Investments Aggregate Intrinsic Value, Options vested and exercisable Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value Estimated useful life of asset Property, Plant and Equipment, Useful Life Derivative Financial Instruments, Liabilities [Member] Derivative Financial Instruments, Liabilities [Member] Vesting of early exercised common stock options Vesting Of Early Excercised Common Stock Options Value Vesting of early excercised common stock options, value. Number of shares of common stock authorized Common Stock, Shares Authorized Common Stock, Shares Authorized Trading Symbol Trading Symbol Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] Subsequent Event Type [Axis] Amortization of right of use assets Operating Lease, Right-of-Use Asset, Amortization Expense Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Redeemable convertible preferred stock liability at a fair value Mandatorily Redeemable Preferred Stock, Fair Value Disclosure Accounts Payable, Current, Total Accounts payable Accounts Payable, Current Fixed-Maturity Securities [Member] Fixed Maturities [Member] Available-for-sale securities, Gross Unrealized Loss Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Available-for-sale securities, Gross Unrealized Loss Total finance lease cost Finance Lease Cost Finance Lease Cost Long-Lived Tangible Asset Long-Lived Tangible Asset [Domain] Collaborative arrangements Collaborative Arrangement, Accounting Policy [Policy Text Block] Common Stock, Par Value Common Stock, Par or Stated Value Per Share Operating lease option to extend Lessee Operating Lease Option To Extend Term Lessee Operating Lease Option To Extend Term. Number of awards, granted Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Property and equipment Property, Plant and Equipment Disclosure [Text Block] Estimated useful life of asset Property, Plant and Equipment, Estimated Useful Lives Weighted average exercise price Granted Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Leases Leases of Lessee Disclosure [Text Block] Stock Conversion Description Stock Conversion Description [Axis] Antidilutive securities excluded from computation of earnings per share, amount Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Cash equivalents Cash and Cash Equivalents, Fair Value Disclosure