Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Volatility, maximum
Impairment of long lived assets
Impairment, Long-Lived Asset, Held-for-Use
Impairment, Long-Lived Asset, Held-for-Use, Total
Common stock vesting period
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Segment information
Segment Reporting, Policy [Policy Text Block]
Restricted stock awards rights vesting
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights
Certificates of Deposit [Member]
Certificates of deposit [Member]
Scenario Forecast
Forecast [Member]
Forecast [Member]
Lease, Cost [Abstract]
Vehicles [Member]
Vehicles [Member]
Number of shares of preferred stock authorized
Temporary Equity, Shares Authorized
Document Information [Line Items]
Auditor Location
Revenue from collaborations recognized in the year
Revenue recognized from collaborative arrangements on upfront payment
Contract With Customer Liability Revenue Recognized on Upfront Payment
Contract with customer liability revenue recognized on upfront payment.
Operating expenses:
Operating Expenses [Abstract]
Investments, Fair Value Disclosure, Total
U.S. Treasury bonds
Investments, Fair Value Disclosure
Fair value, assets
Asset Class
Asset Class [Domain]
Loss from operations
Operating Income (Loss)
Exercise price for incentive stock options as of fair market value
Exercise Price For Incentive Stock Options As Of Fair Market Value Percentage
Exercise price for incentive stock options as of fair market value percentage
Entity Emerging Growth Company
Entity Emerging Growth Company
Income Tax Disclosure [Abstract]
Financial Instrument [Axis]
Proceeds from ESPP purchase
Proceeds from Stock Plans
Number of reportable segments
Number of Reportable Segments
Investments
Marketable Securities, Policy [Policy Text Block]
Payments to Acquire Property, Plant, and Equipment, Total
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Derivative Liabilities And Redeemable Convertible Preferred Stock Liability [Table]
Derivative Liabilities And Redeemable Convertible Preferred Stock Liability [Table]
Derivative Liabilities And Redeemable Convertible Preferred Stock Liability [Table]
Geographical
Geographical [Axis]
Common stock, $0.0001 par value; 320,000,000 shares authorized as of December 31, 2022 and 2021, respectively; 42,922,980 and 42,690,229 shares issued and outstanding as of December 31, 2022 and 2021, respectively
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common Stock, Value, Issued
S-antigen transport-inhibiting oligonucleotide polymers.
S-antigen Transport-inhibiting Oligonucleotide Polymers [Member]
STOPS
Entity Address, State or Province
Entity Address, State or Province
Defined Benefit Plan, Benefit Obligation, Actuarial Gain (Loss)
Actuarial gain (loss)
Interest Income (Expense), Net, Total
Interest income
Interest Income (Expense), Net
Finance lease right of use assets accumulated amortization
Finance Lease, Right-of-Use Asset, Accumulated Amortization
Total liabilities
Liabilities
Risk-free interest rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Operating lease liabilities
Increase Decrease In Operating Lease Liabilities
Increase decrease in operating lease liabilities.
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Derivative Liabilities And Convertible Preferred Stock Liability [Line Items]
Derivative Liabilities And Convertible Preferred Stock Liability [Line Items]
Derivative liabilities and convertible preferred stock liability [line items].
Derivative Financial Instruments, Liabilities [Member]
Derivative Financial Instruments, Liabilities [Member]
Class of Stock
Class of Stock [Domain]
Discontinued Development of Drug Candidates [Abstract]
Discontinued development of drug candidates.
Net periodic benefit cost
Defined Benefit Plan, Net Periodic Benefit Cost (Credit)
Defined Benefit Plan, Net Periodic Benefit Cost (Credit), Total
Weighted average common stock outstanding, basic and diluted
Weighted average shares of common stock, basic and diluted
Weighted Average Number of Shares Outstanding, Basic and Diluted
KU Leuven [Member]
K U Leuven [Member]
KU Leuven.
Estimated useful life of asset
Property, Plant and Equipment, Estimated Useful Lives
Tax credit research and development carryforward expiration year
Tax Credit Research And Development Carryforward Expiration Year
Tax credit research and development carryforward expiration year.
Property and equipment
Deferred Tax Liabilities, Property, Plant and Equipment
Defined contribution plan, matching amount
Defined Contribution Plan, Employer Discretionary Contribution Amount
2018 Equity incentive Plan [Member]
Two Thousand Eighteen Equity Incentive Plan [Member]
2018 Equity incentive Plan
Lab Equipment [Member]
Lab Equipment [Member]
Lab equipment.
Katholieke Universiteit Leuven License Agreement [Member]
Katholieke Universiteit Leuven License Agreement [Member]
Katholieke Universiteit Leuven License Agreement.
General and Administrative [Member]
General and Administrative Expense [Member]
Weighted- Average Remaining Contractual Term, Options vested and exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Restricted Cash, Total
Restricted cash
Restricted Cash
Asset under construction [Member]
Asset under Construction [Member]
Aggregate Fair Value, granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Aggregate Intrinsic Value Granted
Share based compensation arrangement by share based payment award equity instruments other than options aggregate intrinsic value granted.
Voting Common Stock [Member]
Voting Common Stock [Member]
Voting common stock.
Summary of significant accounting policies
Significant Accounting Policies [Text Block]
Revenue recognized from collaborative arrangements
Contract with Customer, Liability, Revenue Recognized
City Area Code
City Area Code
Contractual Obligation, Total
Aggregate payments
Contractual Obligation
Total deferred tax assets
Deferred Tax Assets, Gross
Net deferred tax assets
Deferred Tax Assets, Net of Valuation Allowance
2020 Incentive Award Plan [Member]
Two Thousand And Twenty Incentive Award Plan [Member]
2020 Incentive award plan.
U.S. Treasury bonds [Member]
US Treasury Securities [Member]
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted average exercise price per share Forfeited or expired
Derivative Liabilities And Redeemable Convertible Preferred Stock Liability [Abstract]
Derivative Liabilities And Redeemable Convertible Preferred Stock Liability [Abstract]
Commitments and contingencies (Note 12)
Commitments and Contingencies
Uncertain tax positions changes in period
Uncertain Tax Positions Changes In Period
Uncertain tax positions changes in period.
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Stock issued during the period new issues shares
Issuance of common stock, shares
Stock Issued During Period, Shares, New Issues
Fixed-Maturity Securities, Estimated Fair Value, Total investments
Available-for-sale securities, Amortized Cost
Available-for-sale securities, Estimated Fair Value
Debt Securities, Available-for-sale
Scenario
Scenario [Axis]
Purchase Obligation, Total
Purchase Obligation
Non-cancellable purchase commitments
Basis of presentation
Basis of Accounting, Policy [Policy Text Block]
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Issuance of common stock under employee stock purchase plan (Shares)
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Total
Cash, cash equivalents, and restricted cash, beginning of period
Cash, cash equivalents, and restricted cash, end of period
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Fair value of warrants upon issuance
Fair Value Of Warrants Upon Issuance
Fair value of warrants upon issuance.
Related Party
Related Party [Domain]
Vesting of early exercised options
Vesting Of Early Exercised Options Value
Vesting of early exercised options value.
Income Statement [Abstract]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Net cash and cash equivalents provided by (used in) investing activities
Net Cash Provided by (Used in) Investing Activities
PP&E Purchase still in Accounts Payable
Capital Expenditures Incurred but Not yet Paid
Tax Credit Carryforward
Tax Credit Carryforward [Axis]
Tax Credit Carryforward, Name
Tax Credit Carryforward, Name [Domain]
Employee-related Liabilities, Current, Total
Accrued compensation
Employee-related Liabilities, Current
General and Administrative Expense, Total
General and administrative
General and Administrative Expense
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Total, net
Property and equipment, net
Property, Plant and Equipment, Net
Common Stock, Shares, Issued, Total
Common Stock, Shares, Issued
Common Stock, Shares, Issued
Uncertain tax positions related to liability.
Uncertain Tax Positions Related to Liability
Uncertain tax positions related to liability
Deferred Tax Liabilities, Gross, Total
Total deferred tax liabilities
Deferred Tax Liabilities, Gross
Fixed-Maturity Securities, Amortized Cost, Total investments
Available-for-sale securities, Amortized Cost
Debt Securities, Available-for-sale, Amortized Cost
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Security Exchange Name
Security Exchange Name
Statistical Measurement
Statistical Measurement [Domain]
Estimates future benefit payments, 2028 and thereafter
Defined Benefit Plan, Expected Future Benefit Payment, after Year Five for Next Five Years
Furniture and office equipment [Member]
Furniture and Office Equipment [Member]
Furniture and Fixtures [Member]
Series B-2
Series B Two Preferred Stock [Member]
Series B Two Preferred Stock [Member]
Series B Two Preferred Stock [Member]
Cash and Cash Equivalents, Fair Value Disclosure
Cash and cash equivalents
Cash equivalents
Loss Contingency Accrual, Ending Balance
Loss Contingency Accrual, Beginning Balance
Contingent liabilities
Loss Contingency Accrual
Subsequent Event Type [Domain]
Merck License and Research Collaboration First Amendment
Merck License and Research Collaboration First Amendment [Member]
Merck license and research collaboration first amendment.
Document Period End Date
Document Period End Date
Reconciliation to amounts on the consolidated balance sheet:
Reconciliation To The Amounts On The Condensed Consolidated Balance Sheet [Abstract]
Reconciliation to the amounts on the condensed consolidated balance sheet [Abstract].
Deferred tax assets net operating loss carryforwards expiration year
Deferred Tax Assets Net Operating Loss Carryforwards Expiration Year
Deferred tax assets net operating loss carryforwards expiration year.
Income Statement Location
Income Statement Location [Axis]
Investments
Investments [Domain]
Total
Accrued liabilities
Accrued Liabilities, Current
Summary of Stock Options
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]
Warrants to purchase preferred stock [Member]
Warrant [Member]
Warrant [Member]
Regular Pension Plan [Member]
Regular Pension Plan [Member]
Regular pension plan.
Number of shares of common stock authorized
Common Stock, Shares Authorized
Common Stock, Shares Authorized
Summary of Changes to Unrecognized Tax Benefits
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Use of estimates
Use of Estimates, Policy [Policy Text Block]
Deferred Tax Assets, Deferred Income
Deferred revenue
Long term liabilities
Long Term Liabilities Excluding Deferred Revenue
Long term liabilities excluding deferred revenue.
Less: current portion
Operating lease liabilities, current
Operating Lease, Liability, Current
Accretion of discount on short term investments
Accretion (Amortization) of Discounts and Premiums, Investments
Related Party
Related Party [Axis]
Receviable due from arrangement
Receviable Due From Arrangement
Receviable due from arrangement.
Class of Stock
Class of Stock [Axis]
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Upfront license fees paid
Upfront License Fees Paid
Upfront license fees paid
Antidilutive securities excluded from computation of earnings per share, amount
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Mandatorily Redeemable Preferred Stock [Member]
Mandatorily Redeemable Preferred Stock [Member]
Stock-based compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost
Accrued liabilities
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Summary of changes in fair value for which fair value was determined by Level 3 inputs
Schedule Of Changes In Fair Value Of The Companys Derivative Liability And Redeemable Convertible Preferred Stock Liabilty Table [Text Block]
Schedule of changes in fair value of the company's derivative liability and redeemable convertible preferred stock liability.
Payments for royalties
Payments for Royalties
Effective income tax rate
Effective Income Tax Rate Reconciliation, Percent
Entity Address, Address Line Two
Entity Address, Address Line Two
Current Fiscal Year End Date
Current Fiscal Year End Date
Document Information [Table]
Operating lease cost
Operating Lease, Cost
Finance Lease, Liability, Payment, Due
Finance Lease, Liability, Payment, Due
Other
Deferred Tax Assets, Other
Schedule Of Available For Sale And Held To Maturity Securities Amortised Cost Gross Unrealised Gains Losses And Fair Value [Table]
Schedule Of Available For Sale And Held To Maturity Securities Amortised Cost Gross Unrealised Gains Losses And Fair Value [Table]
Schedule of available for sale and held to maturity securities amortised cost gross unrealised gains losses and fair value [Table].
ASSETS
Assets [Abstract]
Operating and finance lease remaining lease term
Lessee Remaining Lease Term
Lessee remaining lease term of operating and finance lease.
2023
Lessee, Operating Lease, Liability, to be Paid, Year One
Accounts Payable, Current, Total
Accounts payable
Accounts Payable, Current
Fixed-Maturity Securities [Member]
Fixed Maturities [Member]
Common Stock, Par Value
Common Stock, Par or Stated Value Per Share
Schedule of Components of Current Provision for Income Taxes
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
R&D credit carryovers
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
State [Member]
State and Local Jurisdiction [Member]
Beginning balance, Shares
Ending balance, Shares
Shares, Outstanding
Additional Paid in Capital, Common Stock, Ending Balance
Additional Paid in Capital, Common Stock, Beginning Balance
Additional paid-in capital
Additional Paid in Capital, Common Stock
Total current provision for income taxes
Current Income Tax Expense (Benefit)
Warrants issued closing date
Warrants Issued Closing Date
Warrants issued closing date.
Research and development expenses
Research and Development Expense, Policy [Policy Text Block]
Fair Value by Liability Class
Fair Value by Liability Class [Domain]
Percentage of expected average remaining working lives of employees
Percentage Of Expected Average Remaining Working Lives Of Employees
Percentage of expected average remaining working lives of employees.
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Loss before income tax expense
Document Type
Document Type
Investments
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Federal [Member]
Domestic Tax Authority [Member]
Deferred tax assets net operating loss carryforwards ownership change in percentage
Deferred Tax Assets Net Operating Loss Carryforwards Ownership Change In Percentage
Deferred tax assets net operating loss carryforwards ownership change in percentage.
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Income tax examination, tax returns open for examination, period
Income Tax Examination Tax Returns Remain Open For Examination
Income tax examination tax returns remain open for examination.
Preferred Stock, $0.0001 par value; 10,000,000 shares authorized as of December 31, 2022 and 2021, respectively; no shares issued and outstanding as of December 31, 2022 and 2021, respectively.
Preferred Stock, Value, Issued, Ending Balance
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued
Interest on lease liabilities
Finance Lease, Interest Expense
Lease liabilities net of current portion
Operating lease liabilities, net of current portion
Operating Lease, Liability, Noncurrent
Summary of Accrued Liabilities
Schedule of Accrued Liabilities [Table Text Block]
Total current assets
Assets, Current
Luxna license agreement [Member]
Luxna License Agreement [Member]
Luxna license agreement [Member]
Liability Class
Liability Class [Axis]
Change in fair value of derivatives
Effective Income Tax Rate Reconciliation Change In Fair Value Of Derivatives
Effective income tax rate reconciliation change in fair value of derivatives.
Stock-based compensation
Share-based Payment Arrangement [Policy Text Block]
Options to purchase common stock [Member]
Stock Option [Member]
Share-based Payment Arrangement, Option [Member]
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Adjustments to Additional Paid in Capital, Stock Issued, Own-share Lending Arrangement, Issuance Costs
Costs related to the follow-on offering
Federal
Deferred Federal Income Tax Expense (Benefit)
Weighted- Average Remaining Contractual Term, Outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Share based payment exercise price description
Share-based Compensation Arrangement by Share-based Payment Award, Terms of Award
Income Tax Expense (Benefit), Total
Income tax expense
Income Tax Expense (Benefit)
Supplemental disclosures of noncash financing and investing activities:
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Other current assets
Other Assets, Current
Deferred revenue from collaborations
Increase (Decrease) in Deferred Revenue
Earnings Per Share, Basic and Diluted, Total
Net loss per share – basic and diluted
Net loss per share, basic and diluted
Earnings Per Share, Basic and Diluted
Impact of CARES Act to Income Taxes
Impact Of C A R E S Act To Income Taxes
Impact of CARES Act to income taxes.
2027
Finance Lease, Liability, to be Paid, Year Five
Leases [Abstract]
Merck License And Research Collaboration [Member]
Merck license and research collaboration.
Merck License and Research Collaboration
Antidilutive Securities
Antidilutive Securities [Axis]
Principles of consolidation
Consolidation, Policy [Policy Text Block]
Purchases of long-term investments
Payments to Acquire Long-term Investments
Number of awards - Beginning balance
Number of awards - Ending balance
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
First commercial sale of a licensed product period
First Commercial Sale Of A Licensed Product Period
First commercial sale of a licensed product period.
Aggregate Intrinsic Value, options vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding
Common Stock, Shares, Outstanding
State
Current State and Local Tax Expense (Benefit)
Plan Name
Plan Name [Axis]
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Number of options, Forfeited or expired
Disposal Groups, Including Discontinued Operations [Table]
Total deferred provision for income taxes
Deferred provision for income taxes
Deferred Income Tax Expense (Benefit)
Total operating expenses
Operating Expenses
Voting Power
Voting Power [Domain]
Current:
Current Income Tax Expense (Benefit), Continuing Operations [Abstract]
Financial Instruments [Domain]
Available-for-sale securities, Gross Unrealized Loss
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax
Available-for-sale securities, Gross Unrealized Loss
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted average exercise price per share - Beginning balance
Weighted Average Exercise Price Per Share - Ending balance
Cash flows from operating activities:
Net Cash Provided by (Used in) Operating Activities [Abstract]
Discontinued Development of Drug Candidates
Discontinued Development of Drug Candidates [Text Block]
The entire disclosure of discontinued development of drug candidates.
Deferred:
Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract]
Income Tax Contingency [Line Items]
Income Tax Contingency [Line Items]
Less than 10% [Member]
Less Than Ten Percent [Member]
Less than 10%
Assets:
Financial Instruments, Financial Assets, Balance Sheet Groupings [Abstract]
Finance Lease
Finance Lease, Liability, Payment, Due [Abstract]
Debt Securities, Available-for-Sale and Held-to-Maturity, after Allowance for Credit Loss [Abstract]
Warrants exercise price per share
Class of Warrant or Right, Exercise Price of Warrants or Rights
Follow On Offering [Member]
Follow-on offering member.
Follow-on Offering
Follow-on Offering
Available-for-sale securities, Gross Unrealized Gain
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax
APIC, Share-based Payment Arrangement, ESPP, Increase for Cost Recognition
Stock-based compensation expense related to employee stock purchases
Suspension period
Suspension Period Use Of Net Operating Losses
Suspension period use of net operating losses.
Earnings Per Share [Abstract]
Other assets
Increase (Decrease) in Other Current Assets
2024
Lessee, Operating Lease, Liability, to be Paid, Year Two
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Schedule of Expected Income Tax (Benefit) Computed Using Federal Statutory Income Tax Rate to Company's Effective Income Tax Rate
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Compensation Related Costs [Abstract]
Concentrations of credit risk and significant suppliers
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Interest Paid, Including Capitalized Interest, Operating and Investing Activities, Total
Interest paid
Interest Paid, Including Capitalized Interest, Operating and Investing Activities
Debt securities, available-for-sale original maturity period.
Debt Securities, Available-for-sale Original Maturity Period
Investments, maturity period
Weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Research and Development [Member]
Research and Development
Research and Development Expense [Member]
Recently issued accounting standards
Recently Issued Accounting Pronouncements Not Yet Adopted Policy [Text Block]
Recently issued accounting pronouncements not yet adopted [Policy text block].
Document Fiscal Period Focus
Document Fiscal Period Focus
Income tax examination, description
Income Tax Examination, Description
Accounting Policies [Abstract]
Foreign
Current Foreign Tax Expense (Benefit)
Milestone payments and royalties receivable
Milestone Payments And Royalties Receivable
Milestone payments and royalties receivable.
Accumulated other comprehensive income
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Entity Address, Address Line One
Entity Address, Address Line One
Aggregate Intrinsic Value - Exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value
Number of options - Beginning balance
Number of options - Ending balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Impairment of long-lived assets
Impairment or Disposal of Long-Lived Assets, Including Intangible Assets, Policy [Policy Text Block]
Weighted-average discount rate
Finance Lease, Weighted Average Discount Rate, Percent
Retirement Plan Type
Retirement Plan Type [Axis]
Total current liabilities
Liabilities, Current
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Risk-free interest rate, maximum
Aggregate Intrinsic Value - Options outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Lessee, Operating Lease, Liability, to be Paid
Lessee, Operating Lease, Liability, to be Paid
Subsequent Event [Table]
Payments On Deferred Offering Costs
Payments on deferred offering costs.
Payments of deferred offering costs
Lab equipment [Member]
Equipment [Member]
Net cash and cash equivalents used in operating activities
Net Cash Provided by (Used in) Operating Activities
Lessee operating lease area of office space.
Operating lease area of office space
APIC, Share-based Payment Arrangement, Other, Increase for Cost Recognition
Stock-based compensation expense related to employee stock awards
Equity Components
Equity Components [Axis]
Summary of Components of lease Expense
Lease, Cost [Table Text Block]
Current assets:
Assets, Current [Abstract]
Taxable income
Taxable Income
Taxable income.
Summary of Additional Information Related to the Leases
Schedule Of Additional Information Related To The Leases Table [Text Block]
Schedule of additional information related to the leases table text block
Schedule Of Maturities Of Lease Liabilities [Abstract]
Schedule of maturities of lease liabilities [Abstract]
Entity Registrant Name
Entity Registrant Name
Other comprehensive (loss) and income:
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Present value of lease liabilities
Finance Lease, Liability
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Series A Preferred Stock [Member]
Series A
Series A Preferred Stock [Member]
Capital stock
Stockholders' Equity Note Disclosure [Text Block]
Entity Interactive Data Current
Entity Interactive Data Current
Deferred Revenue from collaborations, current
Deferred Revenue From Collaboration Current
Deferred revenue from collaborations current.
Entity Address, City or Town
Entity Address, City or Town
Thereafter
Finance Lease, Liability, to be Paid, after Year Five
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Volatility, minimum
Benefit plans
Postemployment Benefit Plans, Policy [Policy Text Block]
Percentage of principal amount of notes covered by warrants
Percentage Of Principal Amount Of Notes Covered By Warrants
Percentage of principal amount of notes covered by warrants.
Term (in years)
Expected term (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
License and collaboration agreements
License And Collaboration Agreements [Text Block]
License and collaboration agreements text block.
License and collaboration agreements
Trading Symbol
Trading Symbol
Schedule of Fair Value Measurement Valuation Assumptions
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Derivative Liabilities And Redeemable Convertible Preferred Stock Liability [Text Block]
Derivative liabilities and redeemable convertible preferred stock liability.
Derivative liabilities and redeemable convertible preferred stock liability
Cash flows from investing activities:
Net Cash Provided by (Used in) Investing Activities [Abstract]
CAA impact to tax provision
C A A Impact To Tax Provision
CAA impact to tax provision.
Less: imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Local Phone Number
Local Phone Number
Consideration received in the year
Consideration Received
Consideration received.
Total stockholders’ equity
Beginning balance
Ending balance
Stockholders' Equity Attributable to Parent
Subsequent Event Type [Axis]
Other accruals and reserves
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Other
Unrecognized tax benefits
Beginning balance
Ending balance
Unrecognized Tax Benefits
Operating lease, payments
Operating Lease, Payments
Belgium
BELGIUM
Preferred Stock, Shares Issued, Total
Preferred Stock, Shares Issued
Preferred Stock, Shares Issued
Fair value, assets
Assets, Fair Value Disclosure
Statistical Measurement
Statistical Measurement [Axis]
Entity Small Business
Entity Small Business
Increase (Decrease) in Other Operating Liabilities, Total
Increase (Decrease) in Other Operating Liabilities
Other liabilities
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding
Preferred Stock, Shares Outstanding
Deferred Tax Assets, Tax Credit Carryforwards, Total
Tax credits
Deferred Tax Assets, Tax Credit Carryforwards
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Leases
Lessee, Leases [Policy Text Block]
Investment In Available For Sale And Held To Maturity Securities [Table]
Investment In Available For Sale And Held To Maturity Securities [Table]
Investment in available for sale and held to maturity securities [Table].
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
Schedule of Deferred Tax Assets And Liabilities
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Collaboration expire period
Long-term Purchase Commitment, Period
Research and Development Credit [Member]
Research Tax Credit Carryforward [Member]
Royalties due
Accrued Royalties
Common stock voting right
Common Stock, Voting Rights
Estimated useful life of asset
Property, Plant and Equipment, Useful Life
Less: imputed interest
Finance Lease, Liability, Undiscounted Excess Amount
Stock-based compensation
Deferred Tax Liabilities Stock Based Compensation
Deferred tax liabilities stock-based compensation.
Fair value measurements
Fair Value Measurement, Policy [Policy Text Block]
Fair Value Adjustment of Warrants
Change in fair value of derivative liability upon exercise of warrants
Change in fair value
Share based payment awards granted
Number of shares issued
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Granted
Defined benefit plan legal yield guarantee percent
Defined Benefit Plan Legal Yield Guarantee Percent
Defined benefit plan legal yield guarantee percent.
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Incentive tax credits offset amount of tax
Incentive Tax Credits Offset Amount Of Tax
Incentive tax credits offset amount of tax.
Warrants outstanding
Class of Warrant or Right, Outstanding
Voting Common Stock [Member]
Voting Common Stocks [Member]
Voting common stocks.
Warrants issued expiry period
Warrants And Rights Outstanding Maturity Period
Warrants and rights outstanding maturity period.
Other than Temporary Impairment Losses, Investments, Total
Other than temporary impairment losses, investments
Other than Temporary Impairment Losses, Investments
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted average exercise price per share Granted
Right of use assets
Deferred Tax Liabilities Right Of Use Assets
Deferred tax liabilities right of use assets.
Sale of Stock
Sale of Stock [Domain]
Temporary Equity, Shares Issued
Temporary Equity, Shares Issued
Equity [Abstract]
Thereafter
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Capitalized SEC 174 costs
Deferred Tax Assets Capitalized Costs
Deferred tax assets capitalized costs.
Plan Name
Plan Name [Domain]
Other comprehensive income (loss)
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent, Total
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Lessee Lease Description [Table]
Lessee, Lease, Description [Table]
Deferred tax assets:
Components of Deferred Tax Assets [Abstract]
Income Tax Authority
Income Tax Authority [Axis]
Depreciation, Total
Depreciation expense
Depreciation
Lessee, Operating Lease, Term of Contract
Operating lease, term of contract
Increase in valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Non-refundable payment
Long-term Purchase Commitment, Amount
State taxes, net of federal benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Losses on available for sale investments
Gain (Loss) on Sale of Investments, Total
Gain (Loss) on Sale of Investments
(Loss) gain on available for sale investments
Issuance of common stock
Stock Issued During Period, Value, New Issues
Lessee, operating lease, rental payments.
Lessee, operating lease, rental payments
Operating lease rental payments
Summary of Assumptions Used to Determine Grant-date Fair Value of Stock Options
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value [Table Text Block]
Summary of Assumptions Used to Determine Grant-date Fair Value of Stock Option
Re-measurement loss
Foreign Currency Transaction Gain (Loss), before Tax, Total
Foreign Currency Transaction Gain (Loss), before Tax
Share-based Payment Arrangement, Noncash Expense, Total
Stock-based compensation
Share-based Payment Arrangement, Noncash Expense
Effective income tax rate reconciliation, deduction, other
Effective Income Tax Rate Reconciliation, Deduction, Other, Amount
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Research plan funding amount
Research and Development Arrangement, Contract to Perform for Others, Costs Incurred, Gross
Restricted cash
Restricted Cash, Current
Federal
Current Federal Tax Expense (Benefit)
Offset percentage of taxable income
Offset Percentage Of Taxable Income
Offset percentage of taxable income.
Accrued payables
Accrued Payables Current
Accrued payables current.
Number of options vested and exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Net cash and cash equivalents provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Schedule Of Available For Sale And Held To Maturity Securities Amortised Cost Gross Unrealised Gains Losses And Fair Value [Line Items]
Schedule Of Available For Sale And Held To Maturity Securities Amortised Cost Gross Unrealised Gains Losses And Fair Value [Line Items]
Schedule of available for sale and held to maturity securities amortised cost gross unrealised gains losses and fair value [Line items].
Commitments and Contingencies Disclosure [Abstract]
Acquisition of right-of-use asset through operating lease obligation
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Weighted average granted fair date value per share, vested
Total assets
Assets
Level 2 [Member]
Fair Value, Inputs, Level 2 [Member]
Number of options, Exercised
Issuance of common stock upon exercise of stock options, shares
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Statement [Line Items]
Statement [Line Items]
Total liabilities, redeemable convertible preferred stock, and stockholders’ equity
Liabilities and Equity
Fixed-Maturity Securities, Amortized Cost, One year or less
Debt Securities, Available-for-Sale, Amortized Cost, Maturity, Allocated and Single Maturity Date, Year One
Property, Plant and Equipment [Abstract]
Statement of Cash Flows [Abstract]
2025
Finance Lease, Liability, to be Paid, Year Three
Additional Paid-in Capital
Additional Paid-in Capital [Member]
Warrants exercised
Warrants Exercised
Warrants exercised.
Title of 12(b) Security
Title of 12(b) Security
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Subject to Expiration
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Liability for early exercised stock options
Liability For Early Exercised Stocks Options Current
Liability for early exercised stock options current.
Level 3 [Member]
Fair Value, Inputs, Level 3 [Member]
Mark to market adjustments for available-for-sale investments
Market To Market Adjustments For Available For Sale Investments
Market to market adjustments for available for sale investments.
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Revenue from collaborations
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer
Summary of Estimated Useful Life of Asset
Schedule Of Estimated Useful Life Of Asset Table [Text Block]
Schedule of estimated useful life of asset.
Award Type
Award Type [Domain]
Restricted stock awards rights vesting percentage
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Expiration period
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period
2023
Finance Lease, Liability, to be Paid, Year One
2024
Finance Lease, Liability, to be Paid, Year Two
Supplemental disclosures of cash flow information:
Supplemental Cash Flow Elements [Abstract]
Disposal Group Classification [Axis]
Summary of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Level 1 [Member]
Fair Value, Inputs, Level 1 [Member]
Upfront payment received
Upfront Payment Received
Upfront payment received.
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
2026
Lessee, Operating Lease, Liability, to be Paid, Year Four
Total deferred income taxes
Deferred Tax Assets, Net
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Unvested restricted stock [Member]
Restricted Stock [Member]
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Weighted average exercise price Options per share vested and expected to vest
Income Tax Contingency [Table]
Income Tax Contingency [Table]
Number of options, Granted
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Aggregate Fair Value, Beginning balance
Aggregate Fair Value, Ending balance
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Outstanding
Entity Current Reporting Status
Entity Current Reporting Status
Investment Type
Investment Type [Axis]
Entity Voluntary Filers
Entity Voluntary Filers
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Risk-free interest rate, minimum
Scenario
Scenario [Domain]
State net operating loss carryforward
Deferred Tax Assets, Operating Loss Carryforwards, State and Local
Discontinued Operations and Disposal Groups [Abstract]
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted average granted fair date value per share, granted
Risks and uncertainties
Risk And Uncertainity Policy [Text Block]
Risk and uncertainity [Policy text block].
Net loss per share
Earnings Per Share, Policy [Policy Text Block]
Defined contribution plan, matching percentage
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
Income taxes paid
Income Taxes Paid
Redeemable convertible preferred stock liability at a fair value
Beginning balance- Redeemable Convertible Preferred Stock Liability
Ending balance -Redeemable Convertible Preferred Stock Liability
Mandatorily Redeemable Preferred Stock, Fair Value Disclosure
Summary of Stock Based Compensation Expense Was Allocated
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Estimates future benefit payments from 2024 to 2027
Defined Benefit Plan Expected Future Benefit Payment From Year Two To Year Five
Defined benefit plan expected future benefit payment from year two to year five.
Retirement Benefits [Abstract]
Computer equipment [Member]
Computer Equipment [Member]
Computer Equipment [Member]
State
Deferred State and Local Income Tax Expense (Benefit)
Accumulated Other Comprehensive Income (Loss)
AOCI Attributable to Parent [Member]
Auditor Firm ID
Strategic Reprioritization of NASH and COVID-19 Programs
Strategic Reprioritization Of NASH And COVID-19 Programs [Member]
Strategic reprioritization of NASH and COVID-19 programs.
Deferred revenue from collaborations as of December 31
Deferred revenue from collaborations as of January 1
Deferred Revenue From Collaborations
Deferred revenue from collaborations.
Income Statement Location
Income Statement Location [Domain]
Additional upfront payment received
Additional Upfront Payment Received
Additional upfront payment received.
US
UNITED STATES
Auditor Name
Non-voting Common Stock [Member]
Non Voting Common Stocks [Member]
Non-voting common stocks.
Non-Voting Common Stock [Member]
Nonvoting Common Stock [Member]
Number of shares of preferred stock authorized
Preferred Stock, Shares Authorized
Preferred Stock, Shares Authorized
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted average exercise price options per share vested and exercisable
Increase (Decrease) in Accrued Liabilities, Total
Accrued liabilities
Increase (Decrease) in Accrued Liabilities
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total
Unrecognized tax benefits, income tax penalties and interest expense
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Minimum [Member]
Minimum [Member]
Weighted- Average Remaining Contractual Term, Options vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Issuance of common stock upon exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Proceeds from Sale, Maturity and Collection of Short-term Investments, Total
Maturities of short-term investments
Proceeds from Sale, Maturity and Collection of Short-term Investments
Lease liabilities net of current portion
Finance lease liabilities, net of current portion
Finance Lease, Liability, Noncurrent
Cash equivalent qualification, description
Additional Cash and Cash Equivalent Related Text
Fixed-Maturity Securities, Estimated Fair Value, One year or less
Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One
Company contributions
Defined Benefit Plan, Plan Assets, Contributions by Employer
Restricted stock awards granted
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Class of warrant or right, number of securities called by warrants or rights
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Operating Lease
Lessee, Operating Lease, Liability, Payment, Due [Abstract]
Foreign net operating loss carryforward
Deferred Tax Assets, Operating Loss Carryforwards, Foreign
Document Annual Report
Document Annual Report
Aggregate Fair Value, vested
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Vested
Deferred Tax Assets, Valuation Allowance, Total
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Schedule Of Defined Benefit Plans Disclosures [Table]
Schedule of Defined Benefit Plans Disclosures [Table]
Cash flows from financing activities:
Net Cash Provided by (Used in) Financing Activities [Abstract]
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Share based payment unamortised share based payment expenses
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Finance lease right of use assets
Finance Lease, Right-of-Use Asset, before Accumulated Amortization
Foreign currency
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Entity Filer Category
Entity Filer Category
Income taxes
Income Tax, Policy [Policy Text Block]
One-time charge
Severance Costs
Document Fiscal Year Focus
Document Fiscal Year Focus
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Number of options vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average estimated fair value of purchase rights
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Income taxes
Income Tax Disclosure [Text Block]
Gains on pension plans
Gains on pension plans
Other Comprehensive (Income) Loss, Defined Benefit Plan, after Tax and Reclassification Adjustment, Attributable to Parent, Total
Other Comprehensive (Income) Loss, Defined Benefit Plan, after Tax and Reclassification Adjustment, Attributable to Parent
Emory license agreement [Member]
Emory License Agreement [Member]
Emory license agreement.
Research plan expiry period
Research And Development Arrangement Contract To Perform For Others Expiry Period
Research and development arrangement contract to perform for others expiry period.
Entity Ex Transition Period
Entity Ex Transition Period
Fair Value Disclosures [Abstract]
Percentage of workforce reduction
Percentage Of Workforce Reduction
Percentage of workforce reduction.
Property and equipment
Property, Plant and Equipment Disclosure [Text Block]
Short-term lease cost
Short-term Lease, Cost
Income Tax Uncertainties [Abstract]
Maximum [Member]
Maximum [Member]
ROU asset
Increase decrease in right of use assets.
Increase Decrease In Right Of Use Assets
Right of use assets
Entity Central Index Key
Entity Central Index Key
Deferred Revenue from customers, current
Deferred Revenue from Customers Current
Deferred revenue from customers current.
Schedule Of Additional Information Related To The Leases [Abstract]
Schedule of additional information related to the leases
Restricted cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Amortization of right-of-use assets
Finance Lease Amortization Of Right Of Use Assets
Finance lease amortization of right of use assets.
Permanent differences
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Payables and Accruals [Abstract]
Change in pension obligation
Change In Pension Obligation
Change in pension obligation.
Financing Sources [Table]
Financing Sources [Table]
Financing Sources [Table]
Defined Benefit Plan, Funded (Unfunded) Status of Plan, Total
Funded status
Defined Benefit Plan, Funded (Unfunded) Status of Plan
Net pension liability
Cash equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Entity Tax Identification Number
Entity Tax Identification Number
Equity Component
Equity Component [Domain]
Schedule of Deferred Revenue from Collaborative Arrangements
Disclosure of Deferred Revenue from Collaborations [Table Text Block]
Disclosure of deferred revenue from collaborations.
Preferred stock authorized par value
Preferred Stock, Par Value
Preferred Stock, Par or Stated Value Per Share
Volatility
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Property and equipment
Property, Plant and Equipment, Policy [Policy Text Block]
2020 Employee Stock Purchase Plan [Member]
Two Thousand And Twenty Employee Stock Purchase Plan [Member]
2020 employee stock purchase plan.
Finance lease cost:
Finance Lease Costs [Abstract]
Finance lease costs.
Weighted-average remaining lease term (years)
Finance Lease, Weighted Average Remaining Lease Term
Income Tax Authority
Income Tax Authority [Domain]
Expense related to milestone payments
Expense Related To Milestone Payments
Expense related to milestone payments.
Share based payment expenses amortized over a weighted average period
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Deferred revenue from customers
Deferred Revenue from Customers, Non Current
Deferred revenue from customers non current.
Common stock issued upon exercise of stock options
Stock Issues Early Period Share Stock Options Exercised
Stock issues early period share stock options exercised.
Components of Income Tax Expense (Benefit), Continuing Operations [Abstract]
Subsequent Events [Abstract]
Subsequent Event [Line Items]
Leasehold improvements [Member]
Leasehold Improvements [Member]
Leasehold Improvements [Member]
Share based payment Common stock shares authorised
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Top Hat Plan [Member]
Top Hat Plan [Member]
Top Hat Plan.
Statement [Table]
Statement [Table]
Weighted-average remaining lease term (years)
Operating Lease, Weighted Average Remaining Lease Term
Entity File Number
Entity File Number
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Lessee Lease Description [Line Items]
Lessee, Lease, Description [Line Items]
Accumulated Deficit
Retained Earnings [Member]
Product revenue
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Revenue from Contract with Customer, Excluding Assessed Tax
Katholieke Universiteit Leuven [Member]
Katholieke Universiteit Leuven [Member]
Katholieke Universiteit Leuven.
Increase (Decrease) in Accounts Payable, Total
Accounts payable
Increase (Decrease) in Accounts Payable
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Deferred Tax Assets, Operating Loss Carryforwards, Domestic
Net operating loss carryforward
Current liabilities:
Liabilities, Current [Abstract]
Stock-based compensation
Share-based Payment Arrangement [Text Block]
Luxna biotech Co Ltd [Member]
Luxna Biotech Co Ltd [Member]
Luxna biotech Co Ltd [Member]
Subsequent Event [Member]
Subsequent Event
Earnings Per Share, Basic and Diluted [Abstract]
Financial Instruments Financial Assets And Liabilities Balance Sheet Groupings [Abstract]
Financial Instruments Financial Assets And Liabilities Balance Sheet Groupings [Abstract]
Less: current portion
Finance lease liabilities, current
Finance Lease, Liability, Current
Commitments and contingencies
Commitments and Contingencies Disclosure [Text Block]
Aggregate Intrinsic Value, Options vested and exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Present value of lease liabilities
Operating Lease, Liability
Common Stock
Common Stock [Member]
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Total, at cost
Property, Plant and Equipment, Gross
Antisense Oligonucleotide
Antisense Oligonucleotide [Member]
Antisense Oligonucleotide.
Entity Public Float
Entity Public Float
Summary of Available For Sale and Held to Maturity Securities Amortized Cost Gross Unrealized Gains Losses and Fair Value
Summary Of Available For Sale And Held To Maturity Securities Amortized Cost Gross Unrealized Gains Losses And Fair Value Table [Text Block]
Summary of available for sale and held to maturity securities amortized cost gross unrealized gains losses and fair value.
Retirement Plan Type
Retirement Plan Type [Domain]
Cover [Abstract]
Leases
Leases of Lessee Disclosure [Text Block]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted average granted fair date value per share - Ending balance
Weighted average granted fair date value per share - Beginning balance
Asset Class
Asset Class [Axis]
Deferred tax assets, research and development tax credit carryforwards
Deferred Tax Assets, Tax Credit Carryforwards, Research
Deferred tax liabilities:
Components of Deferred Tax Liabilities [Abstract]
Statement of Stockholders' Equity [Abstract]
Summary of Maturities of Lease Liabilities
Schedule Of Maturities Of Lease Liabilities Table [Text Block]
Schedule of maturities of lease liabilities table text block
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment [Table]
Share-based Payment Arrangement [Abstract]
Share-based Payment Arrangement [Abstract]
2026
Finance Lease, Liability, to be Paid, Year Four
Cap period
Cap Period On Use Of Business Incentive Tax Credits
Cap period on the use of business incentive tax credits.
Investment In Available For Sale And Held To Maturity Securities [Line Items]
Investment In Available For Sale And Held To Maturity Securities [Line Items]
Investment in available for sale and held to maturity securities.
Benefit obligation, beginning of year
Benefit obligation, end of year
Defined Benefit Plan, Benefit Obligation
Projected benefit obligation
Cash, cash equivalent and investments
Cash, Cash Equivalents, and Short-term Investments, Total
Cash, Cash Equivalents, and Short-term Investments
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Other
Other Accrued Liabilities, Current
Document Transition Report
Document Transition Report
Share based payments weighted-average grant date fair value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Grant Date Fair Value
Lessee, Operating Lease, Renewal Term
Operating lease renewal option
License And Collaboration Agreements [Abstract]
License and collaboration agreements [Abstract]
Foreign
Deferred Foreign Income Tax Expense (Benefit)
Financing Sources [Line Items]
Financing Sources [Line Items]
Financing Sources [Line Items]
Research and Development Expense, Total
Research and development
Research and Development Expense
Expenses on milestone payments
Expenses On Milestone Payments
Expenses on milestone payments.
Allocated Share Based Compensation Expense
Share based compensation expense
Share-based Payment Arrangement, Expense
Long term purchase commitment additional obligation to be paid
Long Term Purchase Commitment Additional Obligation To Be Paid
Long term purchase commitment additional obligation to be paid.
Statement of Financial Position [Abstract]
Interest and other income, net
Other Operating Income (Expense), Net
Dividends, common stock, cash
Dividends, Common Stock, Cash
Dividend yield
Expected dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Number of awards, vested
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Net decrease in cash, cash equivalents, and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Excluding Exchange Rate Effect
Amortization of right of use assets
Operating Lease, Right-of-Use Asset, Amortization Expense
Defined Benefit Plan, Plan Assets, Amount, Total
Fair value of plan assets, beginning of year
Fair value of plan assets, end of year
Defined Benefit Plan, Plan Assets, Amount
Projected benefit obligation, plan assets
2027
Lessee, Operating Lease, Liability, to be Paid, Year Five
Income tax computed at federal statutory rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Organization
Nature of Operations [Text Block]
Equipment acquired through finance lease
Right-of-Use Asset Obtained in Exchange for Finance Lease Liability
Summary of fair value of the financial instruments that are measured at fair value on a recurring basis
Fair Value, Net Derivative Asset (Liability) Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Aggregate price for share repurchase.
Aggregate price for share repurchase
Aggregate price for share repurchase
Merck [Member]
Merck.
Merck
Long-term Investments, Total
Long-term investments
Long-term Investments
Schedule of Earnings Per Share, Basic and Diluted
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted average exercise price per share Exercised
Emory university [Member]
Emory University [Member]
Emory university [Member]
Long term purchase commitment period description
Longterm Purchase Commitment Period Description
Long term purchase commitment period description.
Servicing Liability at Fair Value, Period Increase (Decrease), Total
Change in fair value of liability
Servicing Liability at Fair Value, Period Increase (Decrease)
Purchases of short-term investments
Payments to Acquire Short-term Investments
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
2025
Lessee, Operating Lease, Liability, to be Paid, Year Three
AUSTRALIA
Australia
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Payment Arrangement, Percent
Stock based compensation
Derivative Liability, Total
Fair value of the warrants
Beginning balance-Derivative Liabilities
Ending balance-Derivative Liabilities
Derivative Liability
Common stock available for future grant
Common Stock, Capital Shares Reserved for Future Issuance
Award Type
Award Type [Axis]
Entity Shell Company
Entity Shell Company
Sale of stock issue price per share
Sale of Stock, Price Per Share
Liabilities and Equity [Abstract]
LIABILITIES, PREFERRED STOCK, AND STOCKHOLDERS' EQUITY
Benefit plans
Retirement Benefits [Text Block]
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of common stock under employee stock purchase plan
Net loss per share
Earnings Per Share [Text Block]
Vesting of early exercised common stock
Vesting Of Early Excercised Common Stock Options Value
Vesting of early excercised common stock options, value.
Summary of Amortized Cost and Estimated Fair Value of Fixed-maturity Securities
Debt Securities Available For Sale And Held To Maturity Table Text Block1
Debt securities available for sale and held to maturity [Table text block].
Amendment Flag
Amendment Flag
Collaborative arrangements
Collaborative Arrangement, Accounting Policy [Policy Text Block]
Voting Power
Voting Power [Axis]
Disposal Group Classification [Domain]
Payments on finance lease
Finance Lease, Principal Payments
Short-term Investments, Total
Short-term investments
Short-term Investments
Sale of Stock, Number of Shares Issued in Transaction
Sale of Stock, Number of Shares Issued in Transaction
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Operating lease liabilities
Deferred Tax Assets Operating Lease Liabilities
Deferred tax assets operating lease liabilities.
Total finance lease cost
Finance Lease Cost
Finance Lease Cost
Shares of common stock held by employees subject to repurchase
Weighted Average Number of Shares, Common Stock Subject to Repurchase or Cancellation
Subsequent events
Subsequent Events [Text Block]
More Than 10% [Member]
More Than Ten Percent [Member]
More Than 10%
Share based compensation expense recognized tax benefit
Share-based Payment Arrangement, Expense, Tax Benefit
Operating lease option to extend
Lessee Operating Lease Option To Extend Term
Lessee Operating Lease Option To Extend Term.
Defined Benefit Plan Disclosure [Line Items]
Defined Benefit Plan Disclosure [Line Items]
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Other Assets, Noncurrent, Total
Other assets
Other Assets, Noncurrent
Employee Stock [Member]
Employee Stock
Geographical
Geographical [Domain]
Increase related to prior year positions
Increase/(decrease) related to prior year positions
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Sale of Stock
Sale of Stock [Axis]
Increase / (decrease) related to current year positions
Unrecognized Tax Benefits, Increase Decrease Resulting from Current Period Tax Positions
Unrecognized tax benefits, Increase decrease resulting from current period tax positions
Components of Deferred Tax Assets and Liabilities [Abstract]
Fair Value Disclosures [Text Block]
Fair value measurements
Proceeds from issuance of common stock
Proceeds from Issuance of Common Stock