100000 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 100010 - Statement - Consolidated balance sheets link:presentationLink link:calculationLink link:definitionLink 100020 - Statement - Consolidated balance sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 100030 - Statement - Consolidated statements of operations and comprehensive loss link:presentationLink link:calculationLink link:definitionLink 100040 - Statement - Consolidated statements of changes in stockholders' equity link:presentationLink link:calculationLink link:definitionLink 100050 - Statement - Consolidated statements of cash flows link:presentationLink link:calculationLink link:definitionLink 100060 - Disclosure - Organization link:presentationLink link:calculationLink link:definitionLink 100070 - Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 100080 - Disclosure - Property and equipment link:presentationLink link:calculationLink link:definitionLink 100090 - Disclosure - Investments link:presentationLink link:calculationLink link:definitionLink 100100 - Disclosure - Accrued liabilities link:presentationLink link:calculationLink link:definitionLink 100110 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 100120 - Disclosure - Derivative liabilities and redeemable convertible preferred stock liability link:presentationLink link:calculationLink link:definitionLink 100130 - Disclosure - Capital stock link:presentationLink link:calculationLink link:definitionLink 100140 - Disclosure - Stock-based compensation link:presentationLink link:calculationLink link:definitionLink 100150 - Disclosure - Fair value measurements link:presentationLink link:calculationLink link:definitionLink 100160 - Disclosure - License and collaboration agreements link:presentationLink link:calculationLink link:definitionLink 100170 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 100180 - Disclosure - Commitments and contingencies link:presentationLink link:calculationLink link:definitionLink 100190 - Disclosure - Benefit plans link:presentationLink link:calculationLink link:definitionLink 100200 - Disclosure - Net loss per share link:presentationLink link:calculationLink link:definitionLink 100210 - Disclosure - Discontinued Development of Drug Candidates link:presentationLink link:calculationLink link:definitionLink 100220 - Disclosure - Subsequent events link:presentationLink link:calculationLink link:definitionLink 100230 - Disclosure - Summary of significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 100240 - Disclosure - Summary of significant accounting policies (Tables) link:presentationLink link:calculationLink link:definitionLink 100250 - Disclosure - Property and equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 100260 - Disclosure - Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 100270 - Disclosure - Accrued liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 100280 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 100290 - Disclosure - Stock-based compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 100300 - Disclosure - Fair value measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 100310 - Disclosure - License and Collaboration Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 100320 - Disclosure - Income taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 100330 - Disclosure - Net loss per share (Tables) link:presentationLink link:calculationLink link:definitionLink 100340 - Disclosure - Organization - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100350 - Disclosure - Summary of significant accounting policies - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100360 - Disclosure - Summary of significant accounting policies - Summary of Estimated Useful Life of Asset (Detail) link:presentationLink link:calculationLink link:definitionLink 100370 - Disclosure - Property and equipment - Summary of Property and Equipment (Detail) link:presentationLink link:calculationLink link:definitionLink 100380 - Disclosure - Property and equipment - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100390 - Disclosure - Investments - Summary of Available For Sale and Held to Maturity Securities Amortized Cost Gross Unrealized Gains Losses and Fair Value (Detail) link:presentationLink link:calculationLink link:definitionLink 100400 - Disclosure - Investments - Summary of Amortized Cost and Estimated Fair Value of Fixed-maturity Securities (Detail) link:presentationLink link:calculationLink link:definitionLink 100410 - Disclosure - Investments - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100420 - Disclosure - Accrued liabilities - Summary of Accrued Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 100430 - Disclosure - Leases - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100440 - Disclosure - Leases - Summary of Maturities of Lease Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 100450 - Disclosure - Leases - Summary of Components of Lease Expense (Detail) link:presentationLink link:calculationLink link:definitionLink 100460 - Disclosure - Leases - Summary of Additional Information Related to the leases (Detail) link:presentationLink link:calculationLink link:definitionLink 100470 - Disclosure - Leases - Summary of Maturities of Lease Liabilities (Detail)2 link:presentationLink link:calculationLink link:definitionLink 100480 - Disclosure - Derivative liabilities and redeemable convertible preferred stock liability - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100490 - Disclosure - Capital stock - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100500 - Disclosure - Stock-based Compensation - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100510 - Disclosure - Stock-based Compensation - Summary of Assumptions Used to Determine Grant-date Fair Value of Stock Options (Detail) link:presentationLink link:calculationLink link:definitionLink 100520 - Disclosure - Stock-based Compensation - Summary of Stock Options (Detail) link:presentationLink link:calculationLink link:definitionLink 100530 - Disclosure - Stock-based Compensation - Summary of Stock Based Compensation Expense Was Allocated (Detail) link:presentationLink link:calculationLink link:definitionLink 100540 - Disclosure - Fair value measurements - Summary of Fair Value of the Financial Instruments that are Measured at Fair Value on a Recurring Basis (Detail) link:presentationLink link:calculationLink link:definitionLink 100550 - Disclosure - License and collaboration agreements - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100560 - Disclosure - License and Collaboration Agreements - Summary of Deferred Revenue from Collaborative Arrangements (Details) link:presentationLink link:calculationLink link:definitionLink 100570 - Disclosure - Income Taxes - Schedule of Components of Current Provision for Income Taxes (Detail) link:presentationLink link:calculationLink link:definitionLink 100580 - Disclosure - Income Taxes - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100590 - Disclosure - Income Taxes - Schedule of Expected Income Tax (Benefit) Computed Using Federal Statutory Income Tax Rate to Company's Effective Income Tax Rate (Detail) link:presentationLink link:calculationLink link:definitionLink 100600 - Disclosure - Income Taxes - Components of Deferred Tax Assets And Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 100610 - Disclosure - Income Taxes - Summary of Changes to Unrecognized Tax Benefits (Detail) link:presentationLink link:calculationLink link:definitionLink 100620 - Disclosure - Commitments and contingencies - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100630 - Disclosure - Benefit plans - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100640 - Disclosure - Net loss per share - Schedule of Earnings Per Share Basic and Diluted (Detail) link:presentationLink link:calculationLink link:definitionLink 100650 - Disclosure - Net loss per share - Schedule of Antidilutive Securities Excluded From Computation of Earnings Per Share (Detail) link:presentationLink link:calculationLink link:definitionLink 100660 - Disclosure - Discontinued Development of Drug Candidates - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100670 - Disclosure - Subsequent events - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink